The De Simone Formulation
unique and certified
by the Inventor
Cutting-edge probiotic product
for gastrointestinal
well-being
and balance
The De Simone Formulation
unique and certified
by the Inventor
Cutting-edge probiotic product
for gastrointestinal
well-being
and balance
research
strains
bacteria per sachet
publications
studies
science speaks for itself
The De Simone Formulation contained in CDS22-formula is the only probiotic formulation recommended and recognized by name in the American College of Gastroenterology AGA guidelines for the management of pouchitis and other pouch-related disorders (Olleik et al., Gastroenterology, Vol. 164, No. 6, 2023).
The European Crohn’s and Colitis Organization (ECCO) has included the De Simone Formulation in its guidelines for the management of Inflammatory Bowel Diseases (IBD) (ECCO, ECCO News, 2023).
CDS22-formula is highly effective in the dietary management of various gastrointestinal conditions. The extensive scientific evidence, comprising over 200 peer-reviewed articles and more than 80 controlled clinical studies, ensures that the benefits observed in clinical trials are replicable in everyday use
why does it work?
Not all probiotics are the same. The overall biological action of a probiotic is not simply the sum of its individual components’ actions but the result of a complex network of relationships between the microorganisms it contains and the human host. Unlike many other products on the market, the clinical results obtained from CDS22-formula speak louder than any technical description.
CDS22-formula combines 8 bacterial strains selected for their biochemical and enzymatic profiles and specifically calibrated in precise proportions to synergistically act on the physiology of the human gastrointestinal tract.
It is crucial to emphasize that the production of the Formulazione De Simone falls within the field of biology, not chemistry, as the bacteria forming the product’s base are living organisms. Their cultivation requires advanced scientific knowledge and specific know-how, still protected by industrial secrecy.
The unique and advanced know-how developed by Prof. Claudio De Simone, which includes specific industrial secrets, contributes to the uniqueness and efficacy of CDS22-formula, making it extremely difficult for others to replicate or produce an identical or functionally equivalent product.
Supported by solid scientific evidence, CDS22-formula is highly effective in the dietary management of dysbiosis and other gastrointestinal conditions, offering proven and replicable clinical results.
benefits
CDS22-formula supports the dietary management of intestinal dysbiosis, contributing to well-being in cases of intestinal disorders connected to irritable bowel syndrome, ulcerative colitis, and pouchitis.
Control of intestinal dysbiosis:
Intestinal dysbiosis is a condition where the natural balance of microorganisms in the intestine is altered, causing various gastrointestinal disorders. Controlling dysbiosis is crucial for maintaining digestive health, improving patient comfort, and contributing to overall well-being, even in cases of chronic intestinal disorders like irritable bowel syndrome, ulcerative colitis, and pouchitis.
Immediate and prolonged restoration of intestinal flora:
CDS22-formula is ideal for both acute and chronic episodes of intestinal dysbiosis.
It reduces the severity and duration of symptoms, improving patient comfort and accelerating recovery. It is particularly indicated for supporting intestinal health and can be beneficial in cases of temporary or chronic intestinal disorders characterized by accelerated transit that prevents normal daily activities or adequate night rest.
Variety of Dosages:
Available in different formats and dosages to support intestinal health and adapt to individual dietary needs, offering flexibility to healthcare professionals in personalizing supplementation.
Original Formulation:
CDS22-formula is the original FormulazionDe Simone, a unique combination of proprietary bacterial strains designed to maximize intestinal well-being. The strains are cultivated and maintained in proprietary Master Cell Banks, ensuring purity, quality, and consistency in every production.
Guaranteed Safety:
Every dose has been tested to ensure maximum efficacy and safety. Thanks to a short supply chain approved by the inventor, the product maintains the highest quality standards from raw material to packaging.
Affordability:
CDS22-formula offers superior value compared to probiotics containing equivalent quantities of bacteria. Efficient production and direct cost control allow us to offer a more affordable product on the market.
De Simone Formulation
The De Simone Formulation contained in CDS22-formula is the result of pioneering research by Professor Claudio De Simone (MD, FAGA), who redefined therapeutic approaches to intestinal health by introducing the use of high-concentration probiotic mixtures to dietetically manage acute and chronic gastrointestinal disorders.
His interest in the intestinal microbiota dates back to the 1980s when the importance of the intestinal flora’s role was just beginning to be understood. Professor De Simone is an honorary member of the American College of Gastroenterology and, after graduating in Medicine and Surgery, specialized in gastroenterology, allergology, and clinical immunology. He taught Infectious Diseases at the University of L’Aquila (Italy).
He has published over 200 clinical studies, scientific articles, and book chapters.
Since the commercial launch of his renowned De Simone Formulation in the 1990s, the Professor has actively advocated for better regulation and quality control of probiotics, highlighting the potential health and well-being risks.
As emphasized by Professor De Simone in numerous conferences and publications, many marketed probiotics have not been clinically tested or may not correspond to the original clinically tested formulations when marketed, causing substantial differences in the safety and efficacy of the final product (De Simone C. Clinical Gastroenterology and Hepatology Vol. 16 No. 9 2018).
Current regulations often do not require thorough comparative studies to ensure that changes in manufacturing processes do not compromise the efficacy and safety of the commercially distributed probiotic product.
there is ONE De Simone Formulation
The lack of strict regulation and the possibility for manufacturers to modify formulations without adequately informing consumers pose a threat to public trust. In the past, the De Simone Formulation (DSF) was sold under the brand name VSL#3®*, by VSL Pharmaceuticals and Actial Srl.
In 2019, VSL#3® distributors were found guilty of false advertising (for more information:Federal Judge Upholds $18M Verdict, Blocks False Advertising of VSL#3, Schulman Bhattacharya). Recently, the European Crohn’s and Colitis Organisation (ECCO) has updated its guidelines to clarify that pre-2016 literature references to VSL#3® exclusively refer to DSF (ECCO, ECCO News, 2023). In 2024, ESPEN (European Society for Clinical Nutrition and Metabolism) published the article “Clarifying Correct Attributions in Scientific Literature: The Case of the De Simone Formulation and VSL#3®“, which reiterates the above.
Soon to be available in the EU under the brand CDS22-formula.
*is a registered trademark of VSL Pharmaceuticals and Actial Srl Inc, independent companies from EOS2021 S.r.l.
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product packaging
CDS22-formula, is available in sachets and capsules to meet specific tastes and needs.
Each format of CDS22-formula is gluten-free and vegetarian.
CDS22-formula 900 billion sachets
Superior power
Designed to offer immediate and powerful support to improve intestinal flora health in critical situations associated with travel, stress, antibiotic therapy, contributing to intestinal well-being, particularly in contexts of acute intestinal disorders or flare-ups.
Potency: 900 billion live bacteria per sachet
CDS22-formula 450 billion sachets
Strong and convenient
Designed for the management of chronic dysbiosis, ensuring optimized daily cost.
Potency: 450 billion live bacteria per sachet
Format: Box of 12 sachets
CDS22-formula 112 billion capsules
Efficient and flexible
The perfect solution for practical and daily support of intestinal flora in individuals susceptible to dietary imbalances.
Potency: 112 billion live bacteria per capsule
Format: Box of 20 individually packaged capsules
- Follow the dosage instructions indicated on the packaging.
- Do not exceed the stated recommended daily dose unless otherwise advised by a doctor.
- Store the product in the refrigerator at a temperature of 2-8°C and away from light. The product can withstand room temperature (max 25°C) for one week without altering its effectiveness.
- CDS22-formula is a food supplement; it does not replace a varied and balanced diet.
- Keep out of reach of young children.
- . This product is not intended for the diagnosis, treatment, cure, or prevention of diseases.
FAQ
CDS22-formula contains the De Simone Formulation, a probiotic formulation of 8 bacterial strains specifically selected for their individual characteristics and mixed in specific proportions to enhance their synergistic action.
These microorganisms work as a cohesive team to achieve results that single strains or other strain combinations cannot reach.
These exclusive strains are stored in proprietary Master Cell Banks, ensuring their origin, high product quality, and the absolute exclusivity of CDS22-formula, CDS22-formula, a unique and inimitable product.
Available in pharmacies starting October 2024.
CDS22-formula contains the De Simone Formulation, a special probiotic blend that helps your intestinal flora maintain or regain balance.
Sachets: Open the sachet and stir the contents into cold water or in any cold non-frizzy drink or food; you can add the sachet’s content into yogurt or apple juice too; consume immediately.
Capsules: Take the capsules with water or a non-carbonated cool beverage.
CDS22-formula is gluten-free and soy-free. It does not contain preservatives or synthetic sweeteners.
Storing CDS22-formula in the refrigerator ensures that the vitality and potency of the bacteria are maintained until expiration. However, it is possible to store the product outside the refrigerator at room temperature for up to a week without compromising quality.
In any case, high temperatures (>25°C) should be avoided.
Although there are no particular risks associated with the use of CDS22-formula, the adaptation of the intestinal flora to the bacteria it contains can occasionally cause transient abdominal bloating, in which case it is advisable to reduce the dosage for a few days.
Yes, CDS22-formula can be taken alongside antibiotic therapy due to the absence of known interactions between these drugs and the microorganisms in the product. To maximize the probiotic’s beneficial effect, it is advisable to take CDS22-formula a few hours after the medication. To maximize the probiotic’s beneficial effect, it is advisable to take CDS22-formula a few hours after the medication.
There are no known contraindications, but it is advisable to consult your doctor before taking any dietary supplement during pregnancy. If you are pregnant, breastfeeding, or taking medications, consult your doctor before using this dietary supplement.
The information provided on this website is for informational purposes only and does not replace medical advice. Always consult a doctor or qualified healthcare professional.
