{"id":1570,"date":"2024-08-09T15:25:51","date_gmt":"2024-08-09T15:25:51","guid":{"rendered":"https:\/\/staging.cds22.com\/about-us\/there-is-one-de-simone-formulation\/"},"modified":"2026-04-09T16:44:12","modified_gmt":"2026-04-09T16:44:12","slug":"there-is-one-de-simone-formulation","status":"publish","type":"page","link":"https:\/\/cds22.com\/ga\/about-us\/there-is-one-de-simone-formulation\/","title":{"rendered":"There is only ONE De Simone Formulation"},"content":{"rendered":"\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\n\t\n\t\n\t\n<\/svg>\t\t<\/div>\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

There is only ONE<\/u> <\/span> De Simone Formulation<\/b>\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\n\t\n\t\n\t\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Now known under the name CDS22-formula<\/em><\/strong>, the De Simone Formulation<\/strong> (DSF)<\/strong> is the same probiotic blend that was previously marketed as VSL#3\u00ae<\/span>*<\/span> by VSL Pharmaceuticals Inc. and Actial S.r.l. <\/p>

However, since February 2016, the product sold under the name VSL#3\u00ae<\/span>* <\/span>no longer contains the original formulation known as the De Simone Formulation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

In 2019, the distributors of VSLVSL#3<\/strong>\u00ae<\/span>*<\/span> were found liable in the United States for false advertising<\/a> and ordered to pay $18 million in damages, along with a permanent injunction against further misleading communications.<\/p>

Following this, the European Crohn\u2019s and Colitis Organisation (ECCO) updated its guidelines to clarify that all scientific references prior to 2016 mentioning VSL#3\u00ae<\/span>*<\/span> refer exclusively to the \u201cDe Simone Formulation<\/strong>\u201d (DSF) (ECCO, ECCO News<\/em>, 2023<\/a>). Supporting this, in 2024, the European Society for Clinical Nutrition and Metabolism (ESPEN) published an article titled “Clarifying Correct Attributions in Scientific Literature: The Case of the De Simone Formulation and VSL#3\u00ae<\/span>*<\/a>“, reinforcing the need to distinguish clearly between DSF and the later formulations sold under the VSL#3\u00ae<\/span>*<\/span> brand. <\/p>

In 2025, a federal class action<\/a> lawsuit was admitted in the United States alleging fraud: consumers claim that distributors continued to sell VSL#3\u00ae<\/span>*<\/span> as if it contained the original formulation by Prof. Claudio De Simone<\/strong>, despite knowing that the composition had been changed in 2016 and lacked evidence of efficacy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

*<\/span>VSL#3\u00ae<\/span> is a registered trademark of VSL Pharmaceuticals Inc. and Actial S.r.l., independent companies unrelated to EOS2021 S.r.l.<\/strong><\/p>

The original De Simone Formulation<\/strong> is now available under:<\/p>

  • USA & Canada: \u201cVisbiome\u00ae<\/span><\/strong>\u201d (ExeGi Pharma LLC)<\/li>
  • South Korea: \u201cDe Simone Formulation\u00ae<\/span><\/strong>\u201d (Hecto Healthcare Co. Ltd.)<\/li><\/ul>

    Now available in the EU & UK under the brand CDS22-formula<\/em>.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    There is only ONE De Simone Formulation Now known under the name CDS22-formula, the De Simone Formulation (DSF) is the same probiotic blend that was previously marketed as VSL#3\u00ae* by VSL Pharmaceuticals Inc. and Actial S.r.l. However, since February 2016, the product sold under the name VSL#3\u00ae* no longer contains the original formulation known as […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1531,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1570","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/pages\/1570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/comments?post=1570"}],"version-history":[{"count":10,"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/pages\/1570\/revisions"}],"predecessor-version":[{"id":6104,"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/pages\/1570\/revisions\/6104"}],"up":[{"embeddable":true,"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/pages\/1531"}],"wp:attachment":[{"href":"https:\/\/cds22.com\/ga\/wp-json\/wp\/v2\/media?parent=1570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}