{"id":582,"date":"2024-06-04T19:41:09","date_gmt":"2024-06-04T19:41:09","guid":{"rendered":"https:\/\/cds22.com\/home\/"},"modified":"2024-09-10T14:54:57","modified_gmt":"2024-09-10T14:54:57","slug":"home","status":"publish","type":"page","link":"https:\/\/cds22.com\/en\/home\/","title":{"rendered":"home"},"content":{"rendered":"\t\t
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The De Simone Formulation<\/strong>
unique and certified
by the Inventor<\/b>\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cutting-edge probiotic product<\/span> \nfor gastrointestinal
well-being \nand balance<\/span>\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The De Simone Formulation<\/strong>
unique and certified
by the Inventor<\/b>\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cutting-edge probiotic product<\/span> \nfor gastrointestinal
well-being \nand balance<\/span>\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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years of
research<\/div>\t\t\t
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selected bacterial
strains<\/div>\t\t\t
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up to 900 billion live
bacteria per sachet<\/div>\t\t\t
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scientific
publications<\/div>\t\t\t
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clinical
studies <\/div>\t\t\t
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science speaks for itself<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The De Simone Formulation contained in CDS22-formula<\/em><\/strong> is the only probiotic formulation recommended and recognized by name in the American College of Gastroenterology AGA<\/strong> guidelines for the management of pouchitis and other pouch-related disorders (<\/strong>Olleik et al., Gastroenterology, Vol. 164, No. 6, 2023<\/a>)<\/strong>.<\/p>\n

The European Crohn\u2019s and Colitis Organization (ECCO)<\/strong> has included the De Simone Formulation in its guidelines for the management of Inflammatory Bowel Diseases (IBD)<\/strong> (ECCO, ECCO News, 2023<\/a>).<\/p>\n

CDS22-formula<\/em><\/strong> is highly effective in the dietary management of various gastrointestinal conditions. The extensive scientific evidence, comprising over 200 peer-reviewed articles<\/strong> and more than 80 controlled clinical studies<\/strong><\/a>, ensures that the benefits observed in clinical trials are replicable in everyday use<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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why does it work?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\"Streptococcus
Streptococcus Thermophilus<\/figcaption><\/figure><\/div>
\"Lactobacillus
Lactobacillus acidophilus<\/figcaption><\/figure><\/div>
\"Lactobacillus
Lactobacillus Plantarum<\/figcaption><\/figure><\/div>
\"Lactobacillus
Lactobacillus paracasei<\/figcaption><\/figure><\/div>
\"Lactobacillus
Lactobacillus helveticus<\/figcaption><\/figure><\/div>
\"Bifidobacterium
Bifidobacterium breve<\/figcaption><\/figure><\/div>
\"Bifidobacterium
Bifidobacterium animalis subsp. lactis<\/figcaption><\/figure><\/div>
\"Bifidobacterium
Bifidobacterium animalis subsp. lactiss<\/figcaption><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t
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Not all probiotics are the same. The overall biological action of a probiotic is not simply the sum of its individual components’ actions but the result of a complex network of relationships between the microorganisms it contains and the human host. Unlike many other products on the market, the clinical results obtained from CDS22-formula<\/em><\/strong> speak louder than any technical description.<\/p>\n

CDS22-formula<\/em><\/strong> combines 8 bacterial strains<\/strong> selected for their biochemical and enzymatic profiles and specifically calibrated in precise proportions to synergistically act on the physiology of the human gastrointestinal tract.<\/p>\n

It is crucial to emphasize that the production of the Formulazione<\/em> De Simone<\/strong> falls within the field of biology, not chemistry, as the bacteria forming the product’s base are living organisms. Their cultivation requires advanced scientific knowledge and specific know-how, still protected by industrial secrecy.<\/p>\n

The unique and advanced know-how developed by Prof. Claudio De Simone<\/strong>, which includes specific industrial secrets, contributes to the uniqueness and efficacy of CDS22-formula<\/em><\/strong>, making it extremely difficult for others to replicate or produce an identical or functionally equivalent product.<\/p>\n

Supported by solid scientific evidence, CDS22-formula<\/em><\/strong> is highly effective in the dietary management of dysbiosis and other gastrointestinal conditions, offering proven and replicable clinical results.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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benefits<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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CDS22-formula<\/em><\/strong> supports the dietary management of intestinal dysbiosis, contributing to well-being in cases of intestinal disorders connected to irritable bowel syndrome, ulcerative colitis, and pouchitis.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Control of intestinal dysbiosis:<\/strong><\/p>\n

Intestinal dysbiosis is a condition where the natural balance of microorganisms in the intestine is altered, causing various gastrointestinal disorders. Controlling dysbiosis is crucial for maintaining digestive health, improving patient comfort, and contributing to overall well-being, even in cases of chronic intestinal disorders like irritable bowel syndrome, ulcerative colitis, and pouchitis.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Immediate and prolonged restoration of intestinal flora:<\/strong><\/p>\n

CDS22-formula<\/em><\/strong> is ideal for both acute and chronic episodes of intestinal dysbiosis.
It reduces the severity and duration of symptoms, improving patient comfort and accelerating recovery. It is particularly indicated for supporting intestinal health and can be beneficial in cases of temporary or chronic intestinal disorders characterized by accelerated transit <\/span>that prevents normal daily activities or adequate night rest.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Variety of Dosages: <\/strong><\/p>\n

Available in different formats and dosages to support intestinal health and adapt to individual dietary needs, offering flexibility to healthcare professionals in personalizing supplementation.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Original Formulation:<\/strong><\/p>\n

CDS22-formula<\/em><\/strong> is the original Formulazion<\/em>De Simone<\/strong>, a unique combination of proprietary bacterial strains designed to maximize intestinal well-being. The strains are cultivated and maintained in proprietary Master Cell Banks, ensuring purity, quality, and consistency in every production.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Guaranteed Safety:<\/strong><\/p>\n

Every dose has been tested to ensure maximum efficacy and safety. Thanks to a short supply chain approved by the inventor, the product maintains the highest quality standards from raw material to packaging.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Affordability:<\/strong><\/p>\n

CDS22-formula<\/em><\/b> offers superior value compared to probiotics containing equivalent quantities of bacteria. Efficient production and direct cost control allow us to offer a more affordable product on the market.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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De Simone Formulation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The De Simone Formulation<\/em><\/strong> contained in CDS22-formula <\/em><\/strong>is the result of pioneering research by Professor Claudio De Simone (MD, FAGA)<\/strong>, who redefined therapeutic approaches to intestinal health by introducing the use of high-concentration probiotic mixtures to dietetically manage acute and chronic gastrointestinal disorders.<\/p>\n

His interest in the intestinal microbiota dates back to the 1980s<\/strong> when the importance of the intestinal flora’s role was just beginning to be understood. Professor De Simone<\/strong> is an honorary member of the American College of Gastroenterology <\/strong> and, after graduating in Medicine and Surgery, specialized in gastroenterology<\/strong>, allergology, and clinical immunology. He taught Infectious Diseases at the University of L’Aquila (Italy).<\/strong><\/p>\n

He has published over 200 clinical studies<\/strong>, scientific articles, and book chapters.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Since the commercial launch of his renowned De Simone Formulation in the 1990s<\/strong>, the Professor has actively advocated for better regulation and quality control of probiotics, highlighting the potential health and well-being risks. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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As emphasized by Professor De Simone<\/strong> in numerous conferences and publications, many marketed probiotics have not been clinically tested or may not correspond to the original clinically tested formulations when marketed, causing substantial differences in the safety and efficacy of the final product (De Simone C. Clinical Gastroenterology and Hepatology Vol. 16 No. 9 2018<\/a>).<\/p>\n

Current regulations often do not require thorough comparative studies to ensure that changes in manufacturing processes do not compromise the efficacy and safety of the commercially distributed probiotic product.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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there is ONE<\/span> De Simone Formulation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The lack of strict regulation and the possibility for manufacturers to modify formulations without adequately informing consumers pose a threat to public trust. In the past, the De Simone Formulation (DSF) was sold under the brand name VSL#3\u00ae*<\/span>, by VSL Pharmaceuticals and Actial Srl.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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In 2019, VSL#3\u00ae distributors were found guilty of false advertising (for more information:Federal Judge Upholds $18M Verdict, Blocks False Advertising of VSL#3, Schulman Bhattacharya<\/a>). Recently, the European Crohn’s and Colitis Organisation (ECCO) has updated its guidelines to clarify that pre-2016 literature references to VSL#3\u00ae exclusively refer to DSF (ECCO, ECCO News, 2023<\/a>). In 2024, ESPEN (European Society for Clinical Nutrition and Metabolism) published the article “Clarifying Correct Attributions in Scientific Literature: The Case of the De Simone Formulation and VSL#3\u00ae<\/a>“, which reiterates the above.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The De Simone Formulation<\/em><\/strong> is sold under the brand name \u201cVisbiome\u201d<\/strong> in the USA and Canada (Exegi) and under the brand name \u201cDe Simone Formulation<\/strong>\u201d in Korea (HectoHealthcare).<\/div>\n
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Soon to be available in the EU under the brand CDS22-formula<\/em>.<\/strong><\/span><\/p>\n

*<\/span>is a registered trademark of VSL Pharmaceuticals and Actial Srl Inc, independent companies from EOS2021 S.r.l.<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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stay informed\n.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Fill out the form below to receive updates on product availability in your Country.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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